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The exposure ranged from 1 cigarette to 60 cigarettes smoked per day, with the 85th percentile of exposure in the exposed group being 26.25 cigarettes smoked per day

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and R x3 is a linear, branched or cyclic, optionally substituted C 1 -C 12 alkyl, C 2 -C 12 alkene or C 2 -C 12 alkyne radical, or a mono- or poly-cyclic aryl comprising 6 to 50 carbon atoms, optionally branched and / or substituted

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