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Its the storage phase not the act of reconstitution that raises concerns about room temperature, since prolonged exposure outside refrigeration accelerates degradation and shortens the solutions usable window

Off / washout (after the block): A typical research framing runs a defined block (commonly 812 weeks) followed by an off period before any subsequent block, rather than indefinite continuous use because long-term human data simply do not exist

This is a classic example of its supportive, rather than primary-driver, role

For those without malabsorption, oral B12 supplements are generally preferred

This selectivity reduces systemic effects seen with full growth hormone