does semaglutide reduce insulin resistance Struggling to Lose Weight? How GLP-1 Helps Does Semaglutide Help With Insulin

Xu, D., Hu, M

Allulose stimulates GLP-1 (a gut hormone that regulates appetite and blood sugar)

In the SOUL trial, published in March 2025 in the New England Journal of Medicine , researchers studied 9,650 participants aged 50 and older with type 2 diabetes and either cardiovascular or kidney disease

Meta-analyses using data from randomized, controlled CV outcomes trials showed that GLP-1 RAs were associated with a significant reduction in the risk of three-component major adverse CV events (CV death, non-fatal myocardial infarction and non-fatal stroke), and a significant reduction in the risk of fatal or non-fatal stroke, versus placebo in addition to standard-of-care (SoC) treatment [13, 14]

Its improved potency is due to the decreased binding of IGF-1 LR3 to all known IGF binding proteins