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Deuschl G, Beghi E, Fazekas F, Varga T, Christoforidi KA, Sipido E, et al

When the EVOKE and EVOKE+ trials failed to meet their primary cognitive endpoints, some headlines framed the outcome as a major blow to the idea that GLP-1 medications could meaningfully impact Alzheimers disease

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BAL fluid and intracellular GSH pathways correlate with HAEC T2-associated gene expression To determine whether these in vitro findings were reflected ex vivo, BAL fluid GSSG levels were compared to fresh HAEC expression of T2-related genes from 2 different RNA-Seq databases (SARP3 and IMSA), which were harmonized and merged as outlined in the Methods (Table 3)