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Physiological blood-brain transport is impaired with age by a shift in transcytosis

Because changes in basal metabolic rate play an important role in body weight homeostasis, energy expenditure (measured by indirect calorimetry) and physical activity (measured by locomotor activity) represent important parameters for gaining further mechanistic insight into anti-obesity drug effects

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The socket is inside the large pelvis bone (acetabulum) and the ball is the upper end of the thighbone (femoral head)

European Medicines Agency decision P/0336/2024 Paediatric Investigation Plan for retatrutide