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[3] These effects are typically mild to moderate and transient during the dose-escalation period

In SUSTAIN 6, the largest trial investigating semaglutide, with the longest duration reported to date in subjects with high cardiovascular risk, mean pulse rate increases of 2.1 and 2.4 bpm were reported with semaglutide 0.5 and 1.0 mg, respectively, versus no change with placebo

Tirzepatide targets an additional receptor, potentially enhancing its effectiveness

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