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Methods: Using a pharmacological approach, we modeled the behavioral and neurochemical effects of subchronic (4-day) nicotine (60g/kg, i.v.) or fluoxetine (1mg/kg, i.v.) exposure in adolescent and adult male rats

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The only problem is, we now know that caffeine is also an addictive drug, whether it is delivered via soft drinks or a coffee mug.6 Numerous researchers have established that caffeine can create a dependence syndrome (see Chapter 3)

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