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Like demise of the horse and buggy, could it be that the same enslaved dopamine pathways that helped replacement nicotine appear superior in more than 200 randomized clinical trials are today, ironically, contributing to its demise

Over the past 50-plus years, tobacco companies have leveraged modern science to manipulate their products to make them even more addictive.The evidence is sufficient to conclude that the increased risk of death and disease specifically lung cancer results from changes in the design and composition of cigarettes since the 1950s, states the surgeon generals The Health Consequences of Smoking 50 Years of Progress report

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