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Notably, the incretin effectamplification of post-prandial insulin secretionis attenuated in MASLD/MASH, type 2 diabetes, and obesity [16]

Expression levels of insulin, TGF-1, -SMA, and collagen I were normalized to that of -actin and expressed relative to that in the sham group [22]

At week 20, the mean changes in body weight and WC were 6.4% and 5.0 cm for the semaglutide group, and 0.8% and 1.1 cm for the placebo group, respectively

Insulin signals the body to store glucose as fat

Conclusion and Next Steps Managing PCOS effectively means finding the right balance between medication and positive lifestyle changes