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This may happen through transcriptional inhibition via NF-B/AP-1 pathways or by altering methyl donor availability (Hassan et al., 2019)

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Perimenopausal women using GLP-1s and experiencing dramatic weight loss may become keenly aware of the potency and widespread nature of weight-related stigma as they notice others, including family, friends, peers, and romantic partners treating them differently because of their weight loss