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A dietary source of TMAO, phosphatidylcholine, is the main risk factor for the development of atherosclerosis, HF, and an elevated risk of mortality [5, 69]

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"Further, while we acknowledge the corrective and preventive actions that your site has taken or plans to take, your written response is inadequate because it does not provide sufficient details about how you, as a clinical investigator, will ensure adequate oversight of the study procedures (for example, adherence to eligibility requirements)