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This ambiguity is partly attributed to the insufficient understanding of the prevalence in the general population of sIgG4 antibodies against food proteins combined with a lack of a concurrent analysis of IgE antibodies, which are traditionally associated to immediate allergic reactions

[23] Some experimental studies have suggested that GLP-1 receptors are expressed in the gastrointestinal tract and may have anti-inflammatory properties, though this research is preliminary and has not been translated into clinical practice

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Chief among these is the vagus nerve, which rapidly conveys information about gut state to the brainstem and vice versa

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