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It crosses the blood-brain barrier and activates the hepatocyte growth factor (HGF) / c-Met receptor pathway, a signaling system that governs neuron survival, synaptic formation, and neural circuit repair

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Furthermore, many patients prescribed tirzepatide for type 2 diabetes are concurrently taking metformin, which independently increases the risk of vitamin B12 deficiency through impaired calcium-dependent B12-intrinsic factor uptake in the ileum

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