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The research team also thought it was important to mention that by week 26 of the experimental period, treatment with semaglutide led to a dose-dependent decrease in mean body weight

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3 In January 2026, the FDA published the largest review to date, analysing 91 placebo-controlled GLP-1 trials covering 107,910 patients alongside a real-world cohort study of 2.2 million patients

They then applied GLP-1 receptor antagonists and the rate increase disappeared completely