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Less sensitive neurotransmitter receptors : Nicotine typically interacts with neurotransmitters like dopamine and acetylcholine, and chronic use can desensitize them over time

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By Thomas Schmid After Chinas Qing dynasty had ceded the island of Formosa (modern Taiwan) to Japan in 1895, the new rulers introduced an informal state monopoly on all tobacco and alcohol products three years later

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