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Such an imbalance is responsible for severe damage to essential biomolecules, such as lipids (lipid peroxidation), proteins (oxidation and inactivation), and DNA (strand breakage and mutations), which is associated with the pathogenesis of numerous diseases, including cancer, neurodegenerative diseases, cardiovascular diseases, and the aging process [28]

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Their direct contact with circulating copper and pro-oxidants (e.g., ox-LDL), combined with limited copper export capacity, creates a precarious copper balance [151, 152]

recent major cardiovascular events

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