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Patients with hepatic impairment generally do not require dose adjustment, as semaglutide is not extensively metabolized by the liver

All participants were on other medications, including diuretics, renin-angiotensin system blockers, and The study had 2 primary endpoints the change in the Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS) and the percentage change in body weight from baseline to week 52

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At baseline, the mean age was 62 years (range 45-93), 72% were male, 84% were White, 4% were Black or African American, and 8% were Asian, and 10% were Hispanic or Latino

Of these reports, 3070 were attributed to Wegovy, originating from 6 countries in 3 continents, and 20,608 to Ozempic, originating from 11 countries in 4 continents