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In tobamovirus Rep protein, the consensus sequences (GXXXXGKT and DEAD box in the helicase domain, and GDD and SGXXXTXXXNT in polymerase domain) were also conserved, except the last amino acid Thr in GXXXXGKT has been substituted by Ser in both the viruses (Figure 4)

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Understanding the immunological consequences of inhaled cannabis products is further complicated by the diversity of products, lack of standardized preclinical models that recapitulate human use patterns and the variation in THC levels that has occurred in cannabis over time

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