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Expert perspectives and off-label use trends

The pronounced dependence of persistent, drug-resistant malignancies on GPX4 underscores its importance, and its inactivation has the potential to eliminate these cancer cells in vitro and avert tumor recurrence in vivo [216]

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However, the discovery of functional extrinsic death receptor-mediated eryptosis and necroptosis of erythrocytes associated with the necrosome formation opens new horizons for our understanding of the possible role of caspases in mature erythrocytes, since caspase-8 might be involved in coordinating the cell fate of mature erythrocytes