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In addition to proliferation arrest, senescent cells also exhibit alterations to their morphology (increased flattening) and metabolism with the activation of the so-called senescence-associated secretory phenotype (SASP), whereby the cells secrete cytokines, chemokines and proteases, that have profound effects on neighbouring cells in the tumour microenvironment (TME) [26,27,28]

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He has no qualms about playing villains He's played child molesters twice ( Sleepers and The Woodsman ), he's been a Marvel supervillain ( X-Men: First Class ), and he's stalked Meryl Streep ( The River Wild ) and Meg Ryan ( In the Cut )

One common example of an arrhythmia is atrial fibrillation, also called AFib

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