a difference between tobacco plantations and cotton and sugar America's first big business? Not the railroads, but slavery Plantation economy - Wikipedia

In 1975, the contribution of the tobacco industry to GDP was 22.9%

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J Clin Invest 111:8190 Wittenberg RE, Wolfman SL, De Biasi M, Dani JA (2020) Nicotinic acetylcholine receptors and nicotine addiction: a brief introduction