Rodriguez WE, Wahlang B, Wang Y, Zhang J, Vadhanam MV, Joshi-Barve S, Bauer P, Cannon R, Ahmadi AR, Sun Z, Cameron A, Barve S, Maldonado C, McClain C, Gobejishvili L (2019) Phosphodiesterase 4 inhibition as a therapeutic target for alcoholic liver disease: from bedside to bench
Quality documentation has long lead times
Athletes using these medications should work closely with sports medicine providers, consider body composition tracking beyond just weight, maintain high protein intake even with reduced appetite, prioritize resistance training, and monitor performance metrics to catch excessive muscle loss early

Project Team: Dr Shane Gordon, NICHE Ulster University (PI) Dr Catherine Hughes, NICHE Ulster University Professor Helene McNulty, NICHE Ulster University Dr Michelle Clements, NICHE Ulster University Dr Fiona Leahy Lithander, University of Auckland Dr Aakash Prasad, University of Auckland Richelle Flanagan, NutritionWise Ireland Willie Wixted, ABC Nutritionals Professor KIERAN TUOHY, University of Leeds Dr Filippos Papadopoulos, Health Economist Key Report findings: Probiotic interventions were linked to improved gastrointestinal health, including an average of one additional bowel movement per week Participants also reported modest improvements in quality of life Economic modelling suggests probiotic support could deliver ~9,000 additional good-health days annually for every 1,000 patients Estimated cost-effectiveness was around 2,400 per QALY, significantly below NHS thresholds The report also highlighted major unmet needs, including persistent constipation, food affordability challenges, and limited access to dietetic support

Medical Disclaimer: The content provided in this newsletter is for informational and educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment