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The non-neuronal nAChR that contain subunits formed by proteins encoded by CHRNA3 and CHRNA5 are expressed in airway cells (bronchial epithelial cells, neutrophil macrophages, monocytes, and lymphocytes) and are also activated when nicotine enters the lungs, causing the release of proteases, pro-inflammatory cytokines, and oxidants that are responsible for lung remodeling, which leads to lung damage after chronic exposure 176 (Fig

Although chewing gum can be traced back to civilizations worldwide, the modernization and commercialization of this product mainly took place in the United States