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doi: 10.7554/eLife.07739

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Interestingly, after this further treatment, significant improvement in steatosis was seen only in patients treated with placebo during the FLIRT, whereas patients who already received rosiglitazone during the FLIRT showed no additional benefit with the longer duration of treatment [47]

FIGURE 3 To further confirm the involvement of AMPK-dependent inhibition on PARP-1 activity in the GLP-1 regulation of ABCA1 expression, PARP-1 knockdown was generated in INS-1 cells by the transfection of si-PARP-1

The number of patients included in the studies ranges from 1 (case report) to 440.089, with a median of 355 (IQR 1295) subjects