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Conversely, if the dose is increased too quickly or if a missed dose is followed by a full dose, side effects can be significantly more intense

Matt Walker Podcast, Reviews & Support Title Card Photo Credit: Mike Blabac Disclaimer Day 31 How to Control Your Sense of Pain & Pleasure | Episode 32 This episode I discuss our sense of pain and pleasure: where and how they each arise in our mind and body and various ways to control their intensity

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Decotiis says

The standard dosing schedule begins at 0.25 mg once weekly for four weeks (initiation dose to improve gastrointestinal tolerability), then increases to 0.5 mg once weekly