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In recent years, the development of epigenetics and molecular biology have provided new guidance for revealing the pathogenesis, diagnosis, and treatment of diseases

Indeed, while nicotine in normal doses is not as dangerous as perceived, the Surgeon Generals report in 2014, The Health Consequences of Smoking50 Years of Progress, surmised that nicotine has acute toxicity at high doses and activates biological pathways that upsurge the risk of disease

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Environ Sci Pollut Res 26:1161811630 Torkashvand J, Godini K, Jafari AJ, Esrafili A, Farzadkia M (2021a) Assessment of littered cigarette butt in urban environment, using of new cigarette butt pollution index (CBPI)

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