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Rates for pipe smokers were similarly high: This group had a 58 percent higher risk of dying from a tobacco-linked cancer during the study period, compared to never-smokers

A recent study reported that cigarette smoke exposure could enhance the expression of inducible nitric oxide synthase (iNOS) and activate nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, both of which contributed to endothelial injury and vascular dysfunction

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