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Like my pipes, though, I dearly love the tobacco ephemera of my pilgrimage, and not long ago put up some of my favorite tins, with just a small nail through the bottom of each tacked into the wall

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Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: a review of published adduct types and levels in humans

Nat Rev Immunol 9 , 377384 (2009)

It is the constant high level of nicotine in the blood that results in the intense addiction found in spit tobacco users