MR is based on three key assumptions: 1) the genetic variants used as instruments for the exposure must be valid and robustly associated with the exposure, 2) there should be no measured or unmeasured confounding of the association between the genetic instrument and the outcome, and 3) the variants should have no independent effect on the outcome other than through the exposure of interest 17
This is refined smoking at its most classic
Similarly, if the FDA takes any encouragement from the outcome of the VLNC experiment, it may well decide that nicotine above a certain level, in any form, via any delivery method, is the next target for a crackdown
One 1R6F cigarette was loaded into the magazine which loaded it into the cigarette holder port
Plus, from New Zealand to the UK, plenty of governments have embraced the idea of a smoke-free future meaning that bans like Mexicos could well become the norm