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Circulating and -cell MOTS-c levels are low in patients with T2D, and systemic MOTS-c treatment prevents pancreatic islet senescence in S961-treated C57BL/6 mice Mitochondrial functions, such as mitochondrial metabolism, ATP or the production of mitochondrial-derived peptides, decline with aging in mice and in patients with T2D 6,8,9,57,58,59,60,61,62,63,64,65,66,67,68,69