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Dark clouds hung over smoking as a likely risky activity long before the watershed case control studies on smoking and lung cancer were published in 1950 by Doll and Hill (on British smokers) and Wynder and Graham (on American smokers)

These chemicals and oxidative substances are toxic to cells, and can: Permanently damage tissues Cause cells to become inflamed Cause cell mutations Switch on carcinogenic genes Impair immune function Stimulate the development of autoimmunity How are Cigarettes Related to Type 2 Diabetes

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She is also known for her starring roles in the box-office hits Ghostbusters , Ghostbusters II , and Avatar

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