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In sum, while mechanistic plausibility is strong and extrapolation from prostate oncology supports the concept of therapeuticwindow expansion, there is presently no highlevel randomized evidence in cervical/gynecologic oncology showing hydrogels expand the therapeutic window (i.e., allowing higher tumor dose or less toxicity at equivalent tumor dose)

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That single chemical addition converts a brief, pulsatile GHRH stimulus into week-long GH and IGF-1 elevation, with once-weekly dosing in human trials versus the multiple daily administrations the no-DAC core's minutes-scale half-life would demand