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F/up2) to acquire details about 1) their respiratory symptoms, 2) smoking status and conventional cigarette consumption per day (cig/day), 3) the number of severe COPD exacerbations in the prior 12 months, 4) post-bronchodilator lung function parameters (forced expiratory flow in 1 second [FEV 1 ]

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Grahams letter explains that he had attended a regional symposium on addictions, during which he had learned that the harms of smoking are almost entirely resident in the smoke, while nicotine is relatively harmless.[26] Therefore, he suggested, it should not be beyond the wit of man to separate nicotine addiction from carcinogenesis

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