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B7-H3 is expressed in different cells in the tumor microenvironment such as cancer cells, cancer stem cells, dendritic cells, pro-tumor type 2 macrophages, myeloid-derived suppressor cells, monocytes, endothelial cells (ECs), NK cells and cancer-associated fibroblasts which indicates the extensive engagement of the B7-H3 ligand/receptor interaction within the tumor region ( Figure 1 Figure 2 5.1 B7-H3 expression in cancer B7-H3 is highly expressed in several cancers ( Figure 2 )