Keywords: fibrosis, GLP1, incretin, MASH, MASLD Abbreviations ACC acetylCoA carboxylase ALT alanine aminotransferases AMPK AMPactivated protein kinase ChREBP carbohydrateresponse elementbinding protein ECM extracellular matrix ELF enhanced liver fibrosis panel FAS fatty acid synthase FAST FibroscanAST score GLP1 glucagon like peptide1 GLP1R glucagonlike peptide1 receptor GLP1RA glucagon like peptide1 receptor agonist HMGCR 3hydroxy3methylglutarylCoA reductase HSC hepatic stellate cells IL6 interleukin6 LSM liver stiffness measurement LTA4 leukotriene A4 MACE major adverse cardiovascular events MASH metabolic dysfunctionassociated steatohepatitis MASLD metabolic dysfunctionassociated steatotic liver disease MCP1 monocyte chemoattractant protein1 SCD1 stearoylCoA desaturase1 SREBP1c sterol regulatory elementbinding protein 1c T2D type 2 diabetes TNF tumour necrosis factor VCTE vibrationcontrolled transient elastography SMA smooth muscle actin Summary

Contact your provider urgently if you experience severe, unrelenting abdominal pain, especially if accompanied by nausea and vomiting
Your journey to achieving and sustaining a healthy weight requires a personalized and comprehensive approach
Last reviewed: July 9, 2026 Last updated: July 9, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Digestive changes are also typical: digestion speeds up, hunger may become more frequent, and bowel patterns can shift