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Lancet 379 (9826): 16021612

Biol Chem 384:50516 Lu GD, Shen HM, Chung MC, Ong CN (2007) Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells

water-insoluble fillers: talc, calcium carbonate, barium sulfate, or ethylcellulose), mucoadhesive agents (starch, chitosan, gelatin, starch, cellulose derivatives), solubilizers, permeation and absorption enhancers (cyclodextrins, fatty acids, phospholipids, surfactants, bile salts, chelating agents) for better therapeutic efficacy [13,14,32,33,34,35,36]

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This research points to a role for Akkermansia in gut-barrier and metabolic health generally