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Initial clinical trials appeared to validate the beneficial effect of incretins, specifically: A small open-label Phase 1 study (2013) with exenatide (Byetta, twice daily, beginning with 5 g/dose for a month and then increased to 10 g/dose) in 45 patients with PD of moderate severity

In the 24-week trial of patients receiving sitagliptin as add-on therapy to insulin (with or without metformin), there were no adverse reactions reported in 5% of patients and more commonly than in patients given placebo, except for hypoglycemia (see Table 3)

Bruin, J

Wait at least 30 minutes before eating, drinking other liquids, or taking other medications

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