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Safety Concerns When Combining These Two Medications The primary safety issue with simultaneous semaglutide and phentermine use involves cardiovascular strain, as both medications can elevate heart rate and blood pressure through different mechanisms

Targeting GLP-1 Receptors As we mentioned above, Semaglutide belongs to the class of glucagon-like peptide-1 (GLP-1) receptor agonists

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commonly reported usable window ~23 weeks