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Desensitisation is a well-recognised issue, which several countries have attempted to minimise, through techniques such as rotating sets of warnings (Australia), supplementary packaging inserts (Canada), and using plain packaging (in progress in various countries) 31,32

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Another study found that the use of menthol IQOS for 5 days by smokers reduced biomarkers of oxidative stress, platelet activation, white blood cell count, and endothelial function, and better lipid metabolism and lung function 100

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