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For type 2 diabetes management , licensed GLP-1 medications include: Exenatide (Byetta, Bydureon) available as twice-daily or once-weekly formulations Liraglutide (Victoza) administered once daily Dulaglutide (Trulicity) given once weekly Semaglutide (Ozempic) administered once weekly as an injection Semaglutide (Rybelsus) taken orally once daily (for type 2 diabetes only, not licensed for weight management) For weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with weight-related comorbidities, two medications hold specific licences: Liraglutide 3.0 mg (Saxenda) once-daily subcutaneous injection Semaglutide 2.4 mg (Wegovy) once-weekly subcutaneous injection Access to these medications through the NHS is governed by NICE guidance
In conclusion, targeted estrogen delivery to non-diabetic islets in the presence of GLP-1 does not enhance GSIS
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