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Besides nicotine, a highly addictive drug, it contains a number of toxic substances including polycyclic aromatic hydrocarbons (PAHs, e.g

Committee on Toxicity of Chemicals in Food CpatE: Statement on the bioavailability of nicotine from the use of oral nicotine pouches and assessment of the potential toxicological risk to users

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excursions permitted to 15 to 30C (59 to 86F) [see USP Controlled Room Temperature]