Mechanism-informed patient selection Biomarker-based stratification: Identifying patients most likely to respond based on mechanistic markers
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Measurements of intracellular haem concentrations To measure protohaem (haem b ) concentrations, LC-UV and LC-MS analyses were performed for quantification and molecular identification, respectively
Symptoms may include facial or throat swelling, difficulty breathing or swallowing, itching or rash, fainting or feeling dizzy, or rapid heartbeat
We believe the mechanism of effect is on calcium channels, and that can reduce transmission of those abnormal nerve signals, often within the peripheral nerve or the spinal cord, says Williams