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The most important factors influencing the decision to recommend or not recommend e-cigarette were patients prior use of nicotine replacement therapy with (SS = 0.22, 95% CI = 0.170.27) and without use of other medications for cessation (SS = 0.18, 95% CI = 0.130.23), and being middle age (50 years old) with chronic obstructive pulmonary disease (SS = 0.16, 95% CI = 0.100.23)