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Given the involvement of differential mtDNA methylation in various diseases and the critical involvement of mitochondrial dysfunction in COPD [30], the aim of the current study was to investigate in airway epithelial cells, whether the CSE-induced dysfunction in mitochondria and changes in mitochondrial gene expression are related to changes in mtDNA methylation

In other words, they noted their work was methodologically weak and their estimates were just that guesses based on their opinions rather than scientific evidence

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