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In support of this, reduced expression of mRNAs coding for bone matrix proteins such as bone sialoprotein (BSP), osteopontin, and osteonectin were also observed with chronic nicotine exposure [24]

damages musculoskeletal and other systems, leading for instance to osteoporosis, lumbar disc disease, and delayed bone and wound healing

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AZI promoted GSH metabolism under CS exposure in vivo To explore the mechanisms involved in the effects of AZI against the airway epithelial barrier dysfunction caused by CS, LCMS was employed and 5602 metabolites were identified in the lung homogenate of SD rats