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: Phase III REGENCY trial demonstrated 46.4% complete renal response vs 33.1% with standard therapy alone Significant improvement in multiple secondary endpoints including proteinuria reduction Consistent safety profile with known oncology indications First anti-CD20 monoclonal antibody with phase III evidence in lupus nephritis : - More convenient administration schedule: four initial doses in first year, then twice-yearly infusions - Option for 90-minute infusions after initial dose - Maintains standard therapy alongside biologic treatment - Requires monitoring for infections and infusion-related reactions "This approval provides a much-needed new option for these patients," said Levi Garraway, MD, PhD, chief medical officer at Roche, highlighting the significant unmet need in lupus nephritis management

Concerns about important biases, such as selection bias, serious confounding by indication, detection bias, or reverse causality, limit the interpretation of some previous observational studies quantifying dementia risk associated with GLP1 receptor agonists (Supplementary Table 14 for further details)

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