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In response to higher prices and changing consumer preferences, companies are adapting their product offerings and developing new product lines, including alternative products, to better meet market demands

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For example, herbal cigarettes with a taro leaf base have approximately the same shelf life as traditional cigarettes, while those using marshmallow or Mullen as a base tend to dry out sooner

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Exclusion criteria were any major recent psychiatric diagnosis, history of conditions that could affect the CNS at scanning other than HIV, daily anti-inflammatory use, unstable medical conditions, and pregnancy