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A U-shaped dose-response and time-of-infusion curve has been documented an important design consideration for DSIP research, as both sub-threshold and supra-threshold doses may produce attenuated effects relative to the optimal dose range

They demonstrated that ZHX2 knockdown increased ferroptosis in Huh7 cells by activating YTHDF2-induced degradation of GPX4 and SLC7A11, suggesting a potential targeted therapeutic pathway [154]