Through LillyDirect at $299 to $449 per month, the annual cost is $3,588 to $5,388
Eli Lillys retatrutide , a triple GIP/GLP-1/glucagon agonist, showed 28.7% weight loss in Phase 3 (December 2025 results) and may be submitted to FDA in late 2026
Cardiovascular Considerations PT-141 can cause transient increases in blood pressure and heart rate, with mean increases of 3-10 mmHg systolic and 2-5 mmHg diastolic pressure observed in clinical trials
MT-II stimulates melanogenesis via MC1R on melanocytes darker pigmentation following short subcutaneous dosing. In the CNS, MT-II can trigger erections without sexual stimulation, pointing to central melanocortin circuitry (hypothalamic and spinal sites). Discovery & Research Milestones Discovery & Research Milestones Originated at the University of Arizona in the 1980s, where researchers were exploring sunless tanning agents. Built as a short, stable analog of -MSH, improving its half-life and activity compared to the natural hormone. Early studies tested Melanotan II in skin pigmentation disorders and sexual dysfunction, but it never achieved regulatory approval
I continue or optimize standard HS treatments, including biologics where indicated, while the GLP-1 agent works on the metabolic side of the equation
