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10,33 With regard to the secondary outcome of HF hospitalisation, the results were neutral, with LEADER showing a non-significant relative risk reduction (RRR) of 13% with liraglutide compared with placebo and SUSTAIN-6 showing no significant difference between the semaglutide and placebo treatment groups

The article explains that these medications act in the hypothalamus, pancreas and gastrointestinal tract, so decisions have to account for renal function, cardiovascular history, diabetes status and prior medication responses

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